Article
Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease.
Clinical science (London, England : 1979) - 1 May 2001
Morris B J, Glenn C L, Wilcken D E, Wang X L
Abstract excerpt
Pathophysiological processes in coronary artery disease (CAD) are influenced by genetic factors. Since (i) inducible nitric oxide synthase (iNOS) has important cardiovascular effects, and (ii) the promoter of the iNOS gene (NOS2A) is genetically modulated by a 4 bp insertion/deletion (+/-) polymorphism located 0.7 kb upstream, we decided to examine the influence of this variant on clinical variables in 856 CAD...
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