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Article

Overexpression of ubiquitin carboxyl-terminal hydrolase L1 arrests spermatogenesis in transgenic mice.

Molecular reproduction and development - 1 Jan 2006

Wang Yu-Lai, Liu Wanzhao, Sun Ying-Jie, Kwon Jungkee, Setsuie Rieko, Osaka Hitoshi, Noda Mami, Aoki Shunsuke, Yoshikawa Yasuhiro, Wada Keiji

Abstract excerpt

Ubiquitin carboxyl-terminal hydrolase 1 (UCH-L1) can be detected in mouse testicular germ cells, mainly spermatogonia and somatic Sertoli cells, but its physiological role is unknown. We show that transgenic (Tg) mice overexpressing EF1alpha promoter-driven UCH-L1 in the testis are sterile due to a block during spermatogenesis at an early stage (pachytene) of meiosis. Interestingly, almost all spermatogonia and...

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PMID: 16177983
DOI: 10.1002/mrd.20364

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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