Article
Relationship between K-ras mutation and the expression of p21WAF1/CIP1 and p53 in chronic pancreatitis and pancreatic adenocarcinoma.
Neoplasma - 1 Jan 2003
Hermanová M, Lukás Z, Kroupová I, Kleibl Z, Novotný J, Nenutil R, Pazourková M, Brázdil J, Kren L, Díte P
Abstract excerpt
Overexpression of p21WAF1/CIP1 was recently described as an early event in the development of pancreatic intraepithelial neoplasia. Since activating K-ras mutations are described in more than 80% of pancreatic cancers and are known to increase intracellular levels of p21WAF1/CIP1 in experimental models, the possible role of activating K-ras mutations in an induction of the p21WAF1/CIP1 expression was investigated...
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