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Article

Double-stranded DNA-induced localized unfolding of HCV NS3 helicase subdomain 2.

Protein science : a publication of the Protein Society - 1 Dec 2003

Liu Dingjiang, Windsor William T, Wyss Daniel F

Abstract excerpt

The NS3 helicase of the hepatitis C virus (HCV) unwinds double-stranded (ds) nucleic acid (NA) in an NTP-dependent fashion. Mechanistic details of this process are, however, largely unknown for the HCV helicase. We have studied the binding of dsDNA to an engineered version of subdomain 2 of the HCV helicase (d(2Delta)NS3h) by NMR and circular dichroism. Binding of dsDNA to d(2Delta)NS3h induces a local unfolding...

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Identifiers

PMID: 14627736
DOI: 10.1110/ps.03280803
PMCID: PMC2366984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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