Article
Association of tumor necrosis factor alpha gene -G308A polymorphism with schizophrenia.
Schizophrenia research - 1 Dec 2003
Schwab Sibylle G, Mondabon Stephanie, Knapp Michael, Albus Margot, Hallmayer Joachim, Borrmann-Hassenbach Margitta, Trixler Matyas, Gross Magdalena, Schulze Thomas G, Rietschel Marcella, Lerer Bernard, Maier Wolfgang, Wildenauer Dieter B
Abstract excerpt
BACKGROUND: Tumor necrosis factor alpha (TNFalpha), a cytokine involved in inflammatory processes, has been implicated in the pathophysiology of schizophrenia. The chromosomal location in the major histocompatibility complex (MHC) region on 6p21.1-21.3, a region with evidence for linkage, suggests a role in susceptibility to schizophrenia. Association of the minor (A) allele of the -G308A TNFalpha gene...
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