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Article

Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens.

5 Dec 1995

Abstract excerpt

The presentation of antigenic peptides by major histocompatibility complex (MHC) class II molecules to CD4+ T cells is critical to the function of the immune system. In this study, we have utilized the sorting signal of the lysosomal-associated membrane protein LAMP-1 to target a model antigen, human papillomavirus 16 E7 (HPV-16 E7), into the endosomal and lysosomal compartments. The LAMP-1 sorting signal...

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PMID: 8524826
DOI: 10.1073/pnas.92.25.11671

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