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Article

Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003

Petryk Anna, Warren James T, Marqués Guillermo, Jarcho Michael P, Gilbert Lawrence I, Kahler Jonathan, Parvy Jean-Philippe, Li Yutai, Dauphin-Villemant Chantal, O'Connor Michael B

Abstract excerpt

The steroid 20-hydroxyecdysone (20E) is the primary regulatory hormone that mediates developmental transitions in insects and other arthropods. 20E is produced from ecdysone (E) by the action of a P450 monooxygenase that hydroxylates E at carbon 20. The gene coding for this key enzyme of ecdysteroidogenesis has not been identified definitively in any insect. We show here that the Drosophila E-20-monooxygenase...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 14610274
DOI: 10.1073/pnas.2336088100
PMCID: PMC283497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Shade is the Drosophila P450 enzyme that mediates the hydroxylation of ecdysone to the steroid insect molting hormone 20-hydroxyecdysone.PMID 14610274Read ↗

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