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Article

Epstein-Barr virus provides a survival factor to Burkitt's lymphomas

5 Nov 2003

Abstract excerpt

Epstein-Barr virus (EBV) has been causally associated with at least five human malignancies. The exact contributions made by EBV to these cancers remain unknown. We demonstrate that one viral protein found in all EBV-associated malignancies, Epstein-Barr nuclear antigen 1 (EBNA-1), is required for survival of one of these cancers, EBV-positive Burkitt's lymphoma. Inhibition of EBNA-1 decreases survival of these...

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PMID: 14603034
DOI: 10.1073/pnas.2336099100

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