Article
TGFB1 promoter polymorphism C-509T and pathophysiology of asthma.
The Journal of allergy and clinical immunology - 1 Mar 2008
Ueda Tetsuya, Niimi Akio, Matsumoto Hisako, Takemura Masaya, Yamaguchi Masafumi, Matsuoka Hirofumi, Jinnai Makiko, Chin Kazuo, Minakuchi Masayoshi, Cheng Lei, Shirakawa Taro, Mishima Michiaki
Abstract excerpt
BACKGROUND: TGF-beta1 can modulate airway inflammation and exaggerate airway remodeling. A polymorphism of a promoter region of TGFB1, C-509T, might be associated with the development of asthma, but its pathophysiologic relevance remains poorly understood. OBJECTIVE: We investigated relations of the C-509T polymorphism to airflow obstruction, sputum eosinophilia, and airway wall thickening, as assessed by means...
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