The Bacillus subtilis Gne (GneA, GalE) protein can catalyse UDP-glucose as well as UDP-N-acetylglucosamine 4-epimerisation.

doi:10.1016/s0378-1119(03)00793-5

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Article

The Bacillus subtilis Gne (GneA, GalE) protein can catalyse UDP-glucose as well as UDP-N-acetylglucosamine 4-epimerisation.

Gene - 13 Nov 2003

Soldo Blazenka, Scotti Claudio, Karamata Dimitri, Lazarevic Vladimir

Abstract excerpt

Mutations in the Bacillus subtilis gene that affect the activity of the uridine diphosphate (UDP)-N-acetylglucosamine (GlcNAc) 4-epimerase (EC 5.1.3.7) were shown to map to galE, the structural gene of the UDP-glucose (Glc) 4-epimerase (EC 5.1.3.2). This genetic evidence that the same enzyme can catalyse the epimerisation of hexoses as well as of their N-acetylated forms is confirmed by in vitro assays with...

Topics

Acetylglucosamine
Bacillus subtilis
Bacterial Proteins
Base Sequence
Catalysis
Escherichia coli
Histidine
Mutation
Recombinant Fusion Proteins
UDPglucose 4-Epimerase
Uridine Diphosphate
Uridine Diphosphate Glucose

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Identifiers

PMID: 14597172
DOI: 10.1016/s0378-1119(03)00793-5

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