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Article

Games played by rogue proteins in prion disorders and Alzheimer's disease.

Science (New York, N.Y.) - 31 Oct 2003

Aguzzi Adriano, Haass Christian

Abstract excerpt

The incidence of Alzheimer's disease (AD) and that of prion disorders (PrD) could not be more different. One-third of octogenarians succumb to AD, whereas Creutzfeldt-Jakob disease typically affects one individual in a million each year. However, these diseases have many common features impinging on the metabolism of neuronal membrane proteins: the amyloid precursor protein APP in the case of AD, and the cellular...

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Identifiers

PMID: 14593165
DOI: 10.1126/science.1087348

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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