Article
High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation.
Blood - 15 Feb 2004
Chiocchetti Annalisa, Indelicato Manuela, Bensi Thea, Mesturini Riccardo, Giordano Mara, Sametti Selina, Castelli Luca, Bottarel Flavia, Mazzarino Maria Clorinda, Garbarini Letizia, Giacopelli Francesca, Valesini Guido, Santoro Claudio, Dianzani Irma, Ramenghi Ugo, Dianzani Umberto
Abstract excerpt
The autoimmune/lymphoproliferative syndrome (ALPS) displays defective function of Fas, autoimmunities, lymphadenopathy/splenomegaly, and expansion of CD4/CD8 double-negative (DN) T cells. Dianzani autoimmune/lymphoproliferative disease (DALD) is an ALPS variant lacking DN cells. Both forms have been ascribed to inherited mutations hitting the Fas system but other factors may be involved. A pilot cDNA array...
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