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Article

Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages.

Human reproduction (Oxford, England) - 1 Nov 2003

Buchholz T, Lohse P, Rogenhofer N, Kosian E, Pihusch R, Thaler C J

Abstract excerpt

BACKGROUND: Successful pregnancies require fine tuning of fibrinolytic activities in order to secure fibrin polymerization and stabilization of the placental basal plate as well as to prevent excess fibrin deposition in placental vessels and intervillous spaces. Fibrinolysis is tightly regulated by plasminogen activator inhibitor-1 (PAI-1). Endothelial PAI-1 synthesis is induced by angiotensin II, which is...

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Source

Identifiers

PMID: 14585904
DOI: 10.1093/humrep/deg474

Genes

ACE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the ACE and PAI-1 genes are associated with recurrent spontaneous miscarriages.PMID 14585904Read ↗

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Are polymorphisms in the ACE and PAI-1 genes associated with recurrent spontaneous miscarriages?Semantic proximity Read ↗

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