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Article

A Pilot Study on Multigenic Thrombophilic Risk in Recurrent Pregnancy Loss: Interactions Between MTHFR Polymorphisms and Classical Thrombophilia-Associated SNPs.

International journal of molecular sciences - 29 Mar 2026

Badulescu Oana-Viola, Hancianu Monica, Mircea Cornelia, Bojan Andrei, Tesoi Dragos-Florin, Vladeanu Maria Cristina, Ciocoiu Manuela, Frasinariu Otilia-Elena, Plesoianu Carmen Elena, Iliescu-Halitchi Dan, Bararu Bojan Iris

Abstract excerpt

Recurrent spontaneous miscarriages represent a significant reproductive challenge, often associated with inherited thrombophilia. Among the genetic factors involved, methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been increasingly studied. The two main variants, MTHFR C677T and MTHFR A1298C, have been suggested to contribute to thrombotic events and adverse pregnancy outcomes. This study aims...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41977299
DOI: 10.3390/ijms27073112
PMCID: PMC13073514

Genes

MTHFR
F2
F5
F13A1
SERPINE1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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