Article
A dominant negative mutant of TLK1 causes chromosome missegregation and aneuploidy in normal breast epithelial cells.
BMC cell biology - 28 Oct 2003
Sunavala-Dossabhoy Gulshan, Li Yuan, Williams Briana, De Benedetti Arrigo
Abstract excerpt
BACKGROUND: In Arabidopsis thaliana, the gene Tousled encodes a protein kinase of unknown function, but mutations in the gene lead to flowering and leaf morphology defects. We have recently cloned a mammalian Tousled-Like Kinase (TLK1B) and found that it phosphorylates specifically histone H3, in vitro and in vivo. We now report the effects that overexpression of a kinase-dead mutant of TLK1B mediates in a normal...
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