Article
Subpopulations of equine infectious anemia virus Rev coexist in vivo and differ in phenotype.
Journal of virology - 1 Nov 2003
Baccam Prasith, Thompson Robert J, Li Yuxing, Sparks Wendy O, Belshan Michael, Dorman Karin S, Wannemuehler Yvonne, Oaks J Lindsay, Cornette James L, Carpenter Susan
Abstract excerpt
Lentiviruses exist in vivo as a population of related, nonidentical genotypes, commonly referred to as quasispecies. The quasispecies structure is characteristic of complex adaptive systems and contributes to the high rate of evolution in lentiviruses that confounds efforts to develop effective vaccines and antiviral therapies. Here, we describe analyses of genetic data from longitudinal studies of genetic...
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