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Article

Iron Accumulation During Cellular Senescence in Human Fibroblasts <i>In Vitro</i>

1 Oct 2003

Abstract excerpt

Iron accumulates as a function of age in several tissues in vivo and is associated with the pathology of numerous age-related diseases. The molecular basis of this change may be due to a loss of iron homeostasis at the cellular level. Therefore, changes in iron content in primary human fibroblast cells (IMR-90) were studied in vitro as a model of cellular senescence. Total iron content increased exponentially...

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PMID: 14580305
DOI: 10.1089/152308603770310158

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