Article
Complete human NF1 cDNA sequence: two alternatively spliced mRNAs and absence of expression in a neuroblastoma line.
DNA and cell biology - 1 Dec 1992
Bernards A, Haase V H, Murthy A E, Menon A, Hannigan G E, Gusella J F
Abstract excerpt
Neurofibromatosis type 1 (NF1) is caused by mutations in a large gene on chromosome 17q11.2. Previously described partial cDNAs for this gene predicted a protein related to yeast IRA1/IRA2 and the mammalian RAS GTPase activator protein GAP. To initiate a detailed study of the role of this gene in...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Base Sequence
- DNA
- Gene Expression
- Genes, Neurofibromatosis 1
- Humans
- Molecular Sequence Data
- Mutation
- Neuroblastoma
- RNA, Messenger
- Tumor Cells, Cultured