Overexpression of peroxisomal malate dehydrogenase MDH3 gene enhances cell death on H2O2 stress in the ald5 mutant of Saccharomyces cerevisiae.

doi:10.1007/s00284-002-3979-z

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Article

Overexpression of peroxisomal malate dehydrogenase MDH3 gene enhances cell death on H2O2 stress in the ald5 mutant of Saccharomyces cerevisiae.

Current microbiology - 1 Sept 2003

Kurita Osamu

Abstract excerpt

Mitochondrial aldehyde dehydrogenase ALD5 of Saccharomyces cerevisiae is involved in the biosynthesis of mitochondrial electron transport chain, and the ald5 mutant is incompetent for respiration. With use of the mutant, we examined the detoxication of H2O2 generation by fatty acid beta-oxidation in peroxisome. The ald5 mutant (AKD321), as well as the 746 rho0 mutant, was more resistant to H2O2 stress than the...

Topics

Aldehyde Oxidoreductases
Catalase
Electron Transport
Gene Expression Regulation, Fungal
Genes, Fungal
Hydrogen Peroxide
Malate Dehydrogenase
Mitochondria
Mutation
Oxidative Stress
Palmitoyl Coenzyme A
Peroxisomes
Saccharomyces cerevisiae

Source

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Identifiers

PMID: 14570268
DOI: 10.1007/s00284-002-3979-z

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