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Article

A twofold increase in <i>BRCA</i> mutation related prostate cancer among Ashkenazi Israelis is not associated with distinctive histopathology

1 Oct 2003

Abstract excerpt

T he magnitude of the risk of prostate cancer among Ashkenazi Jewish carriers of the common mutations in the BRCA1 and BRCA2 genes, the so-called Ashkenazi BRCA founder mutations (BRCA1 185delAG and 5382insC, and BRCA2 6174delT), remains uncertain. Two large epidemiological studies have suggested that the cumulative incidence of prostate cancer among male first degree relatives of individuals with a founder...

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PMID: 14569130
DOI: 10.1136/jmg.40.10.787

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