Article
Colorectal cancer and the CHEK2 1100delC mutation.
Genes, chromosomes & cancer - 1 Aug 2005
de Jong Mirjam M, Nolte Ilja M, Te Meerman Gerard J, van der Graaf Winette T A, Mulder Marcel J, van der Steege Gerrit, Bruinenberg Marcel, Schaapveld Michael, Niessen Renée C, Berends Maran J W, Sijmons Rolf H, Hofstra Robert M W, de Vries Elisabeth G E, Kleibeuker Jan H
Abstract excerpt
The CHEK2 1100delC mutation was recently identified as a low-penetrance breast cancer susceptibility allele. The mutation occurred more frequently in families with clustering of breast and colorectal cancers (CRCs) than in families with clustering of breast cancer only. Hence, the 1100delC mutati...
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