Article
The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton.
The Journal of biological chemistry - 15 Nov 2002
Haddad Luciana A, Smith Nicole, Bowser Mark, Niida Yo, Murthy Vanishree, Gonzalez-Agosti Charo, Ramesh Vijaya
Abstract excerpt
Tuberous sclerosis complex, an autosomal dominant disease caused by mutations in either TSC1 or TSC2, is characterized by the development of hamartomas in a variety of organs. The proteins encoded by TSC1 and TSC2, hamartin and tuberin, respectively, associate with each other forming a tight complex. Here we show that hamartin binds the neurofilament light chain and it is possible to recover the hamartin-tuberin...
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