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Article

Malin and laforin are essential components of a protein complex that protects cells from thermal stress

8 Jun 2011

Abstract excerpt

The heat-shock response is a conserved cellular process characterized by the induction of a unique group of proteins known as heat-shock proteins. One of the primary triggers for this response, at least in mammals, is heat-shock factor 1 (HSF1)--a transcription factor that activates the transcription of heat-shock genes and confers protection against stress-induced cell death. In the present study, we...

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PMID: 21652633
DOI: 10.1242/jcs.082800

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