Article
Analysis of T cell receptor variable regions and complementarity determining region 3 of infiltrating T lymphocytes in the liver of patients with chronic type B hepatitis.
Intervirology - 1 Jan 2003
Maru Yasushi, Yokosuka Osamu, Imazeki Fumio, Saisho Hiromitsu, Omata Masao
Abstract excerpt
OBJECTIVES: T cell receptor (TCR) variable regions and complementarity determining regions 3 (CDR3) of infiltrating T cells in the livers of patients with chronic hepatitis B were examined in detail. METHODS: TCR usage was examined by the inverse polymerase chain reaction in 2 hepatitis B e antigen-positive patients, one at an early stage and the other at an advanced stage. RESULTS: In 61 productively rearranged...
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