Article
Transduction of green fluorescent protein increased oxidative stress and enhanced sensitivity to cytotoxic drugs in neuroblastoma cell lines.
Molecular cancer therapeutics - 1 Sept 2003
Goto Hiroaki, Yang Bo, Petersen Denise, Pepper Karen A, Alfaro Paul A, Kohn Donald B, Reynolds C Patrick
Abstract excerpt
Green fluorescent protein (GFP) is employed as a selection marker for gene transduction and to track tumor cells. Transduction of enhanced GFP (eGFP) into human neuroblastoma cell lines via a lentiviral vector significantly sensitized CHLA-20 (wild-type and functional TP53), and to a lesser extent CHLA-90 cells (multidrug-resistant, mutant, and nonfunctional TP53) to carboplatin, doxorubicin, etoposide, or...
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