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Article

Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations.

The New England journal of medicine - 9 Oct 2003

Wilschanski Michael, Yahav Yaacov, Yaacov Yasmin, Blau Hannah, Bentur Lea, Rivlin Joseph, Aviram Micha, Bdolah-Abram Tali, Bebok Zsuzsa, Shushi Liat, Kerem Batsheva, Kerem Eitan

Abstract excerpt

BACKGROUND: Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene containing a premature termination signal cause a deficiency or absence of functional chloride-channel activity. Aminoglycoside antibiotics can suppress premature termination codons, thus permitting trans...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14534336
DOI: 10.1056/NEJMoa022170

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14534336-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations.PMID 14534336Read ↗

A pilot study of the effect of gentamicin on nasal potential difference measurements in cystic fibrosis patients carrying stop mutations.Semantic proximity Read ↗

No detectable improvements in cystic fibrosis transmembrane conductance regulator by nasal aminoglycosides in patients with cystic fibrosis with stop mutations.Semantic proximity Read ↗

Pharmacologic therapy for stop mutations: how much CFTR activity is enough?Semantic proximity Read ↗

In vitro prediction of stop-codon suppression by intravenous gentamicin in patients with cystic fibrosis: a pilot study.Semantic proximity Read ↗

Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations.Semantic proximity Read ↗

Restoration of W1282X CFTR Activity by Enhanced ExpressionSemantic proximity Read ↗

Correction of CFTR function in nasal epithelial cells from cystic fibrosis patients predicts improvement of respiratory function by CFTR modulators.Semantic proximity Read ↗

Ataluren (PTC124) Induces Cystic Fibrosis Transmembrane Conductance Regulator Protein Expression and Activity in Children with Nonsense Mutation Cystic FibrosisSemantic proximity Read ↗

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Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse carrying a human CFTR-G542X transgene.Semantic proximity Read ↗

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