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Article

Restoration of W1282X CFTR Activity by Enhanced Expression

31 May 2007

Abstract excerpt

Cystic fibrosis results from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Premature termination codons represent a common minority of CFTR mutations, and are caused by base pair substitutions that produce abnormal stop codons in the coding sequence. Select aminoglycosides induce "translational readthrough" of premature stop codons and have been shown to restore full-length...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 17541014
DOI: 10.1165/rcmb.2006-0176oc

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