Article
SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission.
Neuropharmacology - 1 Nov 2003
Finley Michael F A, Scheller Richard H, Madison Daniel V
Abstract excerpt
Phorbol esters, activators of protein kinase C (PKC), have been shown to enhance synaptic transmission. One potential downstream target of PKC in the presynaptic terminal is the soluble N-ethylmaleimide sensitive factor (NSF) attachment protein receptor (SNARE) SNAP-25, which has a PKC phosphorylation site in its C-terminal coil centered at serine 187 (S187/Ser187). We examined the role of S187 in hippocampal...
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