Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.

The Journal of biological chemistry - 12 Dec 2003

Davie Judith K, Edmondson Diane G, Coco Cherie B, Dent Sharon Y R

Abstract excerpt

The Tup1-Ssn6 corepressor complex in Saccharomyces cerevisiae represses the transcription of a diverse set of genes. Chromatin is an important component of Tup1-Ssn6-mediated repression. Tup1 binds to underacetylated histone tails and requires multiple histone deacetylases (HDACs) for its repressive functions. Here, we describe physical interactions of the corepressor complex with the class I HDACs Rpd3, Hos2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin
Share to Fungal Proteins
Share to Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylases

Share to Immunoblotting

Share to Precipitin Tests

Share to Repressor Proteins

Share to Schizosaccharomyces pombe Proteins

Source

Identifiers

PMID: 14525981
DOI: 10.1074/jbc.M309753200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.PMID 14525981Read ↗

Histone-dependent association of Tup1-Ssn6 with repressed genes in vivo.Semantic proximity Read ↗

Repression domain of the yeast global repressor Tup1 interacts directly with histones H3 and H4.Semantic proximity Read ↗

NuA4 lysine acetyltransferase Esa1 is targeted to coding regions and stimulates transcription elongation with Gcn5.Semantic proximity Read ↗

Gene regulation by the yeast Ssn6-Tup1 corepressor.Semantic proximity Read ↗

HISTONE DEACETYLASE6 Acts in Concert with Histone Methyltransferases SUVH4, SUVH5, and SUVH6 to Regulate Transposon Silencing.Semantic proximity Read ↗

Tfb6, a previously unidentified subunit of the general transcription factor TFIIH, facilitates dissociation of Ssl2 helicase after transcription initiation.Semantic proximity Read ↗

Structure and biological importance of the Spn1-Spt6 interaction, and its regulatory role in nucleosome binding.Semantic proximity Read ↗

Sfl1 functions via the co-repressor Ssn6-Tup1 and the cAMP-dependent protein kinase Tpk2.Semantic proximity Read ↗

NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.Semantic proximity Read ↗

Essential functional interactions of SAGA, a Saccharomyces cerevisiae complex of Spt, Ada, and Gcn5 proteins, with the Snf/Swi and Srb/mediator complexes.Semantic proximity Read ↗

A role for transcriptional repressors in targeting the yeast Swi/Snf complex.Semantic proximity Read ↗

Crystal structure of human LDB1 in complex with SSBP2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.