Article
Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene.
Biochemical and biophysical research communications - 17 Oct 2003
Bizimungu Christelle, De Neve Nancy, Burny Arsène, Bach Stéphane, Bontemps Françoise, Portetelle Daniel, Vandenbol Micheline
Abstract excerpt
The yeast proteins Msb3p and Msb4p are two Ypt/Rab-specific GTPase-activating proteins (GAPs) involved in cell growth polarization. Both proteins share with a wide variety of other proteins the highly conserved TBC domain forming the catalytically active RabGAP domain. In particular, Msb3p and Msb4p are similar to the human proteins oncTre210p (the 786-amino-acid product of the human Tre2 oncogene, implicated in...
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