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Article

Variation in the PDE4D gene and ischemic stroke risk: a systematic review and meta-analysis on 5200 cases and 6600 controls.

Stroke - 1 Jul 2008

Bevan Steve, Dichgans Martin, Gschwendtner Andreas, Kuhlenbäumer Gregor, Ringelstein E B, Markus Hugh S

Abstract excerpt

BACKGROUND AND PURPOSE: PDE4D was identified as the first novel gene associated with ischemic stroke risk. Replication studies have produced conflicting results, but many have been small and underpowered. Meta-analysis provides a method to combine this data and determine in a larger sample size whether the association with PDE4D can be replicated. METHODS: A meta-analysis of all PDE4D variants investigated in...

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Identifiers

PMID: 18420948
DOI: 10.1161/STROKEAHA.107.509992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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