Article
Endothelin-1 stimulates arterial VCAM-1 expression via NADPH oxidase-derived superoxide in mineralocorticoid hypertension.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2003
Li Lixin, Chu Yi, Fink Gregory D, Engelhardt John F, Heistad Donald D, Chen Alex F
Abstract excerpt
Although hypertension is a major risk factor for atherosclerosis, its underlying mechanisms remain to be delineated. We have recently reported that both endothelin-1 (ET-1) and vascular cellular adhesion molecule-1 (VCAM-1) levels, key early markers of atherosclerosis, are significantly elevated in carotid arteries of deoxycorticosterone acetate (DOCA)-salt hypertensive rats, a model known for its suppressed...
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