A balanced complex chromosomal rearrangement (BCCR) in a family with reproductive failure.

doi:10.1093/humrep/deg424

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Article

A balanced complex chromosomal rearrangement (BCCR) in a family with reproductive failure.

Human reproduction (Oxford, England) - 1 Oct 2003

Lespinasse J, North M O, Paravy C, Brunel M J, Malzac P, Blouin J L

Abstract excerpt

Balanced complex chromosomal rearrangements are very rare events in the human population. Translocations involving three or more chromosomes frequently lead to a severe reproductive impairment secondary to meiotic disturbance in males and to chromosomal imbalance in gametes of females. We report a new familial case of complex chromosome anomaly involving chromosomes 13, 14 and 22. Cytogenetic investigations...

Topics

Adult
Chromosome Segregation
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 22
Cytogenetic Analysis
DNA
Female
Gene Rearrangement
Genotype
Humans
In Situ Hybridization, Fluorescence
Infertility
Karyotyping
Meiosis
Pedigree
Translocation, Genetic

Source

Open in PubMed

Identifiers

PMID: 14507821
DOI: 10.1093/humrep/deg424

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