Article
Balanced complex chromosome rearrangement in male infertility: case report and literature review.
Andrologia - 1 Mar 2015
Nguyen M H, Morel F, Pennamen P, Parent P, Douet-Guilbert N, Le Bris M J, Basinko A, Roche S, De Braekeleer M, Perrin A
Abstract excerpt
Complex chromosome rearrangements (CCRs) are structural rearrangements involving at least three chromosomes and three or more chromosome breakpoints. Generally, balanced CCR carriers have a normal phenotype but they are at a higher reproductive risk. Azoospermia was discovered in the male partner of a couple with primary infertility. Conventional cytogenetics identified a CCR refined by fluorescent in situ...
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