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The role of neurotrophin receptors in female germ-cell survival in mouse and human

30 Sept 2003

Abstract excerpt

During mammalian ovary formation, the production of ovarian follicles is accompanied by an enormous loss of germ cells. It is not known how this loss is regulated. We have investigated the role of the Trk tyrosine kinase receptors, primarily TrkB, in this process. The ovaries of TrkB-/- and TrkC-/- mice with a mixed (129Sv x C57BL/6) genetic background were examined shortly after birth. Around 50% of TrkB-/- mice...

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PMID: 14507777
DOI: 10.1242/dev.00707

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