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Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults

26 Apr 2006

Abstract excerpt

The signals initiating the growth of primordial follicles are unknown. Growth factors such as neurotrophin 4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) may play a role in this process. To investigate the expression of NT-4/5 and BDNF and their receptor tyrosine kinase B (TrkB) in the early developing follicles, we fixed and froze 12 ovarian samples from adolescents/adults and 31 ovaries from human...

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PMID: 16648150
DOI: 10.1093/molehr/gal033

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