Back to search

Article

Antimalarial and <i>Plasmodium falciparum</i> serpentine receptor 12 targeting effect of a purinergic receptor antagonist FDA approved drug

2020-12-17

Abstract excerpt

Intraerythrocytic stages of Plasmodium falciparum responsible for all clinical manifestations of malaria are regulated by array of signaling cascades and effector molecules that represents attractive targets for antimalarial therapy. G-protein coupled receptors (GPCRs) are druggable targets in treatment of various pathological conditions however there is limited understanding about the role of GPCRs in malaria pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7fa5dd0b-b1af-5b76-8a6c-1a7371403ff2
DOI
10.1101/2020.12.16.423179
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Antimalarial and <i>Plasmodium falciparum</i> serpentine receptor 12 targeting effect of a purinergic receptor antagonist FDA approved drugDOI 10.1101/2020.12.16.423179
Genome-Wide Detection of Serpentine Receptor-Like Proteins in Malaria ParasitesSemantic proximity
Evidence of G-Protein-Coupled Receptors (GPCR) in the Parasitic Protozoa Plasmodium falciparum—Sensing the Host Environment and Coupling within Its Molecular Signaling ToolkitSemantic proximity
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparumSemantic proximity
Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease <i>Pf</i> ROM8 and cation channel <i>Pf</i> CSC1Semantic proximity
Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasiteSemantic proximity
A Potent Kalihinol Analogue Disrupts Apicoplast Function and Vesicular Trafficking in <i>P. falciparum</i> MalariaSemantic proximity
Pf SRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete FormationSemantic proximity
An equivalence of prokaryotic pore forming proteins of Plasmodium triggers cellular dysfunction responsible for malaria pathogenesisSemantic proximity
Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New DrugsSemantic proximity
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide AnaloguesSemantic proximity
A G-Protein-Coupled Receptor Modulates Gametogenesis via PKG-Mediated Signaling Cascade in Plasmodium bergheiSemantic proximity
Signalome-wide assessment of erythrocyte response to <i>Plasmodium</i> reveals novel targets for host-directed antimalarial interventionSemantic proximity
Select a neighboring publication to make it the new centre.