Patterns of expression of the six alternatively spliced exons affecting the structures of the COL1 and NC2 domains of the alpha 1(XIII) collagen chain in human tissues and cell lines.

Abstract excerpt

Reverse transcription-polymerase chain reactions and RNA protection experiments were used to examine alternative splicing of the six exons 3B-5, 12, and 13 affecting the COL1 and NC2 domains of type XIII collagen in seven human tissues and four cell lines. Distinct differences in the proportions of the variant mRNAs were found. With respect to the COL1 domain, all studied samples contained mRNAs corresponding to...

Topics

• Alternative Splicing
• Base Sequence
• Cell Line
• Collagen
• Exons
• Gene Expression
• Genetic Variation
• Humans
• Macromolecular Substances
• Molecular Sequence Data
• Oligodeoxyribonucleotides