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Article

Adoptive transfer of skin-selective autoimmunity induced by Skn alloantigenic disparities.

Proceedings of the National Academy of Sciences of the United States of America - 15 Nov 1992

Jackman S H, Boyse E A, Goldberg E H

Abstract excerpt

Two unlinked genes of the mouse, Skn-1 and Skn-2, each with alterative alleles, specify alternative cell-surface Skn alloantigens expressed only by epidermal and neural cells. C57BL/6 (B6) and A/J (A) strain mice differ at both Skn loci. Thus lethally irradiated B6 mice restored with (B6 x A)F1 hybrid hematopoietic cells [(B6 x A)/B6 chimeras] reject A strain (Skn-incompatible) skin grafts. Our studies were...

Topics

Alleles
Animals
Autoimmunity
Chimera
Graft Rejection
Immunotherapy, Adoptive
Lymphocytes
Mice
Mice, Inbred A
Mice, Inbred C57BL
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Skin

Skin Transplantation

Spleen

Source

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Identifiers

PMID: 1438311
DOI: 10.1073/pnas.89.22.11041
PMCID: PMC50479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1438311-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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