Article
Cellular heterogeneity and mutant oestrogen receptors in hormone resistant breast cancer.
Cancer surveys - 1 Jan 1992
Horwitz K B
Abstract excerpt
In summary, we propose that the molecular heterogeneity of ER in breast tumour cells, characterized by the presence of mutant receptor forms, generates the cellular heterogeneity evident when PR or DNA ploidy are analysed in cell subpopulations. Furthermore, it is likely that cellular heterogeneity leads to the lack of uniformity in response to tamoxifen that we have described. We find that heterogeneity of PR...
Topics
- Breast Neoplasms
- Cell Division
- Chromosome Mapping
- Female
- Genetic Variation
- Humans
- Neoplasms, Hormone-Dependent
- RNA, Messenger
- Receptors, Estrogen
- Receptors, Progesterone
- Tamoxifen