How do breast cancers become hormone resistant?

doi:10.1016/0960-0760(94)90271-2

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Article

How do breast cancers become hormone resistant?

The Journal of steroid biochemistry and molecular biology - 1 Jun 1994

Horwitz K B

Abstract excerpt

We propose that the molecular heterogeneity of estrogen receptors (ER) in breast tumor cells characterized by the presence of mutant receptor forms, generates the cellular heterogeneity evident when progesterone receptor (PR) or DNA ploidy are analyzed in cell subpopulations. Furthermore, it is l...

Topics

Amino Acid Sequence
Breast Neoplasms
Drug Resistance
Estrogens
Female
Humans
Molecular Sequence Data
Mutation
Progestins
Receptors, Estrogen
Receptors, Progesterone
Tamoxifen

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