Cultured fibroblasts in avian scleroderma, an autoimmune fibrotic disease, display an activated phenotype.

doi:10.1016/0896-8411(92)90157-l

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Article

Cultured fibroblasts in avian scleroderma, an autoimmune fibrotic disease, display an activated phenotype.

Journal of autoimmunity - 1 Oct 1992

Duncan M R, Wilson T J, Van De Water J, Berman B, Boyd R, Wick G, Gershwin M E

Abstract excerpt

University of California, Davis, line 200 and 206 chickens spontaneously develop an autoimmune syndrome that has many features analogous to human scleroderma, including dermal fibrosis, antinuclear antibodies and antibodies to type II collagen. These birds also have thymic subcapsular epithelial defects and an abnormality in T cell calcium influx and proliferation in response to both T cell receptor-dependent and...

Topics

Animals
Autoimmune Diseases
Cell Division
Cells, Cultured
Chickens
Collagen
Disease Models, Animal
Fibroblasts
Glycosaminoglycans
Phenotype
Scleroderma, Systemic

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