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Article

Role of tryptophan 49 in the heparin cofactor activity of human antithrombin III.

The Journal of biological chemistry - 25 Oct 1992

Gettins P, Choay J, Crews B C, Zettlmeiss G

Abstract excerpt

To probe the functional role of tryptophan 49 in human antithrombin III, a mutant antithrombin, W49K, has been expressed in baby hamster kidney cells. The mutation reduces the affinity for heparin pentasaccharide by 1.8 kcal mol-1 but does not alter the heparin enhancement of the rate of factor Xa inhibition. 1H NMR spectra of W49K antithrombin show that the structure of the protein and the mode of heparin...

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PMID: 1400504

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Role of tryptophan 49 in the heparin cofactor activity of human antithrombin III.PMID 1400504Read ↗

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