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Article

Cloning of aklavinone biosynthesis genes from Streptomyces galilaeus.

The Journal of antibiotics - 1 Aug 1992

Tsukamoto N, Fujii I, Ebizuka Y, Sankawa U

Abstract excerpt

Aklavinone is an aglycone of aclacinomycin A which is an important antitumor drug. Genes for the biosynthesis of aklavinone were cloned from Streptomyces galilaeus 3AR-33, an aklavinone-producing mutant, by use of the actI and actIII polyketide synthase gene probes. Restriction mapping and Southern analysis of the DNA cloned in a lambda phage vector established that the DNA represented three different regions of...

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Source

Identifiers

PMID: 1399850
DOI: 10.7164/antibiotics.45.1286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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