Cloning of aklavinone biosynthesis genes from Streptomyces galilaeus.

doi:10.7164/antibiotics.45.1286

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Article

Cloning of aklavinone biosynthesis genes from Streptomyces galilaeus.

The Journal of antibiotics - 1 Aug 1992

Tsukamoto N, Fujii I, Ebizuka Y, Sankawa U

Abstract excerpt

Aklavinone is an aglycone of aclacinomycin A which is an important antitumor drug. Genes for the biosynthesis of aklavinone were cloned from Streptomyces galilaeus 3AR-33, an aklavinone-producing mutant, by use of the actI and actIII polyketide synthase gene probes. Restriction mapping and Southe...

Topics

Antibiotics, Antineoplastic
Cloning, Molecular
Gene Library
Genes, Bacterial
Genetic Complementation Test
Multienzyme Complexes
Mutation
Naphthacenes
Streptomyces

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