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Article

Molecular analysis of gamma-globin promoters, HS-111 and 3'HS1, in beta-thalassemia intermedia patients associated with high levels of Hb F.

Hemoglobin - 1 Jan 2009

Hamid Mohammad, Mahjoubi Frouzandeh, Akbari Mohammad T, Arab Aida, Zeinali Sirous, Karimipoor Morteza

Abstract excerpt

The nucleotide (nt) variations in the promoter region of the gamma-globin genes, HS-111 and 3'HS1 regions, were studied in Iranian patients with beta-thalassemia intermedia (beta-TI), beta-thalassemia major (beta-TM) and healthy individuals. Of the five nt variations at the 5' end of the (A)gamma-globin gene, -369 (C>G), -611 (-T) and -603/604 (GA>AG) were found in all samples, whereas -588 (A>G) and -AAGC at...

Topics

Case-Control Studies
Fetal Hemoglobin
Gene Frequency
Genetic Markers
Humans
Iran
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
beta-Thalassemia
gamma-Globins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19958188
DOI: 10.3109/03630260903336479

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19958188-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Molecular analysis of gamma-globin promoters, HS-111 and 3'HS1, in beta-thalassemia intermedia patients associated with high levels of Hb F.PMID 19958188Read ↗

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