Article
Saponin adjuvant induction of ovalbumin-specific CD8+ cytotoxic T lymphocyte responses.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1992
Newman M J, Wu J Y, Gardner B H, Munroe K J, Leombruno D, Recchia J, Kensil C R, Coughlin R T
Abstract excerpt
The ability of a saponin adjuvant, QS-21, to induce OVA-specific, class I MHC Ag-restricted CTL was investigated using different forms of soluble OVA and OVA adsorbed onto alum as immunogens. C57BL/6 mice were immunized with soluble native or denatured OVA in formulations that contained increasing quantities of QS-21, and CTL responses were measured using EL4 and E.G7-OVA cells as targets and splenic mononuclear...
Topics
- Adjuvants, Immunologic
- Amino Acid Sequence
- Animals
- CD8 Antigens
- Epitopes
- Female
- Histocompatibility Antigens Class I
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Ovalbumin