Article
Saponin adjuvant induction of ovalbumin-specific CD8+ cytotoxic T lymphocyte responses.
Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1992
Newman M J, Wu J Y, Gardner B H, Munroe K J, Leombruno D, Recchia J, Kensil C R, Coughlin R T
Abstract excerpt
The ability of a saponin adjuvant, QS-21, to induce OVA-specific, class I MHC Ag-restricted CTL was investigated using different forms of soluble OVA and OVA adsorbed onto alum as immunogens. C57BL/6 mice were immunized with soluble native or denatured OVA in formulations that contained increasing quantities of QS-21, and CTL responses were measured using EL4 and E.G7-OVA cells as targets and splenic mononuclear...
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