Article
DNA-analysis of patients with autosomal dominant polycystic kidney disease.
Folia medica - 1 Jan 1992
Dimitrakov D, Kalaidzhieva L, Bogdanov N, Dragova D
Abstract excerpt
Indirect DNA analysis was performed on 12 families totalling 80 people. The analysis used five genetic markers flanking the gene: 3'HVR, pGGG, 218 EP6, 24-1, 26-6. In 11 of the families (92%), a linkage with the PKD1 gene in chromosome 16 was established. In one family, the disease did not segregate with the polymorphic markers of PKD1-locus, thus excluding any possibility that a mutation in this locus was the...
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