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Article

Common genes associated with antidepressant response in mouse and man identify key role of glucocorticoid receptor sensitivity

28 Dec 2017

Abstract excerpt

Response to antidepressant treatment in major depressive disorder (MDD) cannot be predicted currently, leading to uncertainty in medication selection, increasing costs, and prolonged suffering for many patients. Despite tremendous efforts in identifying response-associated genes in large genome-wide association studies, the results have been fairly modest, underlining the need to establish conceptually novel...

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PMID: 29283992
DOI: 10.1371/journal.pbio.2002690

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