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Article

Structure and function of the tryptophan synthase alpha(2)beta(2) complex. Roles of beta subunit histidine 86.

The Journal of biological chemistry - 17 Dec 1999

Ro H S, Miles E W

Abstract excerpt

To probe the structural and functional roles of active-site residues in the tryptophan synthase alpha(2)beta(2) complex from Salmonella typhimurium, we have determined the effects of mutation of His(86) in the beta subunit. His(86) is located adjacent to beta subunit Lys(87), which forms an internal aldimine with the pyridoxal phosphate and catalyzes the abstraction of the alpha-proton of L-serine. The...

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Identifiers

PMID: 10593940
DOI: 10.1074/jbc.274.51.36439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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