Article
Ordering gene function: the interpretation of epistasis in regulatory hierarchies.
Trends in genetics : TIG - 1 Sept 1992
Avery L, Wasserman S
Abstract excerpt
The order of action of genes in a regulatory hierarchy that is governed by a signal can often be determined by the method of epistasis analysis, in which the phenotype of a double mutant is compared with that of single mutants. The epistatic mutation may be in either the upstream or the downstream gene, depending on the nature of the two mutations and the type of regulation. Nevertheless, when the regulatory...
Topics
- Animals
- Epistasis, Genetic
- Gene Expression Regulation
- Mutation
- Signal Transduction